Data Extraction

Last modified

NOTE: Do the same for Semantic MEDLINE Prototype. Difference? Yes!

Note: Access to the Semantic MEDLINE application and database requires signing the UMLS Metathesaurus license agreement which I have done.

Semantic MEDLINE

Go To: http://skr3.nlm.nih.gov/SemMed/

Step 1

The Search Tab Is Also the Home Page: http://skr3.nlm.nih.gov/SemMed/Welcome.do

Query: Alzheimer's Disease

Most Recent: 100

Check All Three Boxes: Full Text, Free Full Text, and Abstracts

Search: See First 20 of 100 Citations Below


Found 100 citations. Showing 1 to 20
Pages: Prev 1 | 2 | 3 | 4 | 5 | Next

Citations

 
Uribe V, Wong B, Graham R, Cusack C e, Skotte N, Pouladi M, Xie Y, Feinberg K, Ou Y, Ouyang Y, Deng Y, Franciosi S, Bissada N, Spreeuw A, Zhang W, Ehrnhoefer D, Vaid K, Miller F, Deshmukh M, Howland D, Hayden M. 
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice. 
22262731
Abstract
Baumkötter F, Wagner K, Eggert S, Wild K, Kins S. 
Structural aspects and physiological consequences of APP/APLP trans-dimerization. 
21952790
Abstract
Ding Y, Ko M, Pehar M, Kotch F, Peters N, Luo Y, Salamat S, Puglielli L. 
Biochemical Inhibition of the Acetyltransferases ATase1 and ATase2 Reduces β-Secretase (BACE1) Levels and Aβ Generation. 
22267734
Abstract
Okamoto Y, Yamamoto T, Kalaria R, Senzaki H, Maki T, Hase Y, Kitamura A, Washida K, Yamada M, Ito H, Tomimoto H, Takahashi R, Ihara M. 
Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts. 
22170742
Abstract
van Schadewijk A, van't Wout E, Stolk J, Hiemstra P. 
A quantitative method for detection of spliced X-box binding protein-1 (XBP1) mRNA as a measure of endoplasmic reticulum (ER) stress. 
22038282
Abstract
Rosen R, Fritz J, Dooyema J, Cintron A, Hamaguchi T, Lah J, LeVine H, Jucker M, Walker L. 
Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats. 
22017494
Abstract
Cunningham C, Skelly D. 
Non-steroidal anti-inflammatory drugs and cognitive function: are prostaglandins at the heart of cognitive impairment in dementia and delirium? 
21932048
Abstract
Tardiff D, Tucci M, Caldwell K, Caldwell G, Lindquist S. 
Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms. 
22147697
Abstract
Haley G, Berteau-Pavy F, Berteau-Pavy D, Raber J. 
Novel image-novel location object recognition task sensitive to age-related cognitive decline in nondemented elderly. 
21234692
Abstract
Leal M, Surace E, Holgado M, Ferrari C, Tarelli R, Pitossi F, Wisniewski T, Castaño E, Morelli L. 
Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Aβ metabolism. 
22036964
Abstract
Hochstrasser T, Marksteiner J, Humpel C. 
Telomere length is age-dependent and reduced in monocytes of Alzheimer patients. 
22178633
Abstract
Poksay K, Banwait S, Crippen D, Mao X, Bredesen D, Rao R. 
The small chaperone protein p23 and its cleaved product p19 in cellular stress. 
21691801
Abstract
Brouwers N, Cauwenberghe C, Engelborghs S, Lambert J, Bettens K, Bastard N, Pasquier F, Montoya A, Peeters K, Mattheijssens M, Vandenberghe R, Deyn P, Cruts M, Amouyel P, Sleegers K, Broeckhoven C. 
Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites. 
21403675
Abstract
Cai Y, Zhang X, Macklin L, Cai H, Luo X, Oddo S, Laferla F, Struble R, Rose G, Patrylo P, Yan X. 
BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer's disease: differential Aβ antibody labeling of early-onset axon terminal pathology. 
21725719
Abstract
Briones N, Dinu V. 
Data mining of high density genomic variant data for prediction of Alzheimer's disease risk. 
22273362
Abstract
Capone R, Jang H, Kotler S, Kagan B, Nussinov R, Lal R. 
Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions. 
22242635
Abstract
Chen S, Chen T, Lai L, Chen J, Sun Y, Wen L, Yip P, Chu Y, Chen Y. 
Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease. 
22272811
Abstract
Chiu C, Miller M, Caralopoulos I, Worden M, Brinker T, Gordon Z, Johanson C, Silverberg G. 
Temporal course of cerebrospinal fluid dynamics and amyloid accumulation in the aging rat brain from three to thirty months. 
22269091
Abstract
Kern F, Sarg B, Stasyk T, Hess D, Lindner H. 
The Nogo receptor 2 is a novel substrate of Fbs1. 
22206664
Abstract
Braunewell K. 
The visinin-like proteins VILIP-1 and VILIP-3 in Alzheimer's disease-old wine in new bottles. 
22375104
Abstract

Click on Article Link: Some Have Link to Full Text. See Example: http://www.ncbi.nlm.nih.gov/pubmed/21952790?dopt=AbstractPlus

Click on Abstract Link: Get a Popup with Astract - But It Does Not Have a URL

Abstract


Apoptosis, or programmed cell death, is a cellular pathway involved in normal cell turnover, developmental tissue remodeling, embryonic development, cellular homeostasis maintenance and chemical-induced cell death. Caspases are a family of intracellular proteases that play a key role in apoptosis. Aberrant activation of caspases has been implicated in human diseases. In particular, numerous findings implicate Caspase-6 (Casp6) in neurodegenerative diseases, including Alzheimer disease (AD) and Huntington disease (HD), highlighting the need for a deeper understanding of Casp6 biology and its role in brain development. The use of targeted caspase-deficient mice has been instrumental for studying the involvement of caspases in apoptosis. The goal of this study was to perform an in-depth neuroanatomical and behavioral characterization of constitutive Casp6-deficient (Casp6-/-) mice in order to understand the physiological function of Casp6 in brain development, structure and function. We demonstrate that Casp6-/- neurons are protected against excitotoxicity, nerve growth factor deprivation and myelin-induced axonal degeneration. Furthermore, Casp6-deficient mice show an age-dependent increase in cortical and striatal volume. In addition, these mice show a hypoactive phenotype and display learning deficits. The age-dependent behavioral and region-specific neuroanatomical changes observed in the Casp6-/- mice suggest that Casp6 deficiency has a more pronounced effect in brain regions that are involved in neurodegenerative diseases, such as the striatum in HD and the cortex in AD.

Step 2

Click on Summarization Tab: http://skr3.nlm.nih.gov/SemMed/InitializeSummary.do

See:  (Query: Alzheimer's Disease, Source: Medline, Most Recent: 100, Start Date: 01/01/1900, End Date: 01/31/2012, 100 citations retrieved., 379 predications extracted.)

Summary Type: Treatment of Disease (Also Substance Interactions, Diagnosis, and Pharamcogenomics) Note: The Terms (Numbers) Below Change With These Categories (I do not know why!)

More Relation: Check Box (I do not know why!)

Chose File and Upload Visualize: (I do not know how to use this!)

See Spreadsheet For Totals (379?)

Treatment of Disease

Found 40 predications. Showing 1 to 20
Pages: Prev 1 | 2 | Next
PMID Sentence Subject Predicate Object
21199446 The memory dysfunctions that characterize Alzheimer's disease (AD) are strongly correlated with synapse loss. Memory impairment COEXISTS_WITH Alzheimer's Disease
21234692 Previously, the novel image-novel location (NINL) object recognition test was shown to be sensitive to detect effects of apolipoprotein E4, a risk factor for developing age-related cognitive decline and Alzheimer's disease, in nondemented elderly. Alzheimer's Disease PROCESS_OF Elderly
21891973 In addition, curcumin labeled some diffuse SPs negative for Congo red in the AD, monkey, bear, and APP Tg-mouse brains. Curcumin TREATS Alzheimer's Disease
21891973 Some SPs in the AD, monkey, dog, bear, and amyloid precursor protein transgenic mouse (APP Tg-mouse) brains contained congophilic materials, and were intensely positive for curcumin. Senile Plaques COEXISTS_WITH Alzheimer's Disease
21911655 PARTICIPANTS: The intent-to-treat sample consisted of 104 adults with amnestic mild cognitive impairment (n = 64) or mild to moderate AD (n = 40). Alzheimer's Disease PROCESS_OF Adult
21911655 Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Insulin TREATS Alzheimer's Disease
21911655 OBJECTIVE: To examine the effects of intranasal insulin administration on cognition, function, cerebral glucose metabolism, and cerebrospinal fluid biomarkers in adults with amnestic mild cognitive impairment or Alzheimer disease (AD). Alzheimer's Disease PROCESS_OF Adult
21911655 OBJECTIVE: To examine the effects of intranasal insulin administration on cognition, function, cerebral glucose metabolism, and cerebrospinal fluid biomarkers in adults with amnestic mild cognitive impairment or Alzheimer disease (AD). Administration, Intranasal TREATS Alzheimer's Disease
21911655 Both insulin doses also preserved general cognition as assessed by the ADAS-cog score for younger participants and functional abilities as assessed by the ADCS-ADL scale for adults with AD (P < .05). Alzheimer's Disease PROCESS_OF Adult
21932048 This suggests that the primary mediator targeted by these drugs, PGE2, is not actively suppressing memory function in AD. Dinoprostone TREATS Alzheimer's Disease
21949904 This paper discusses recent findings of the multimodal MRI in the context of surrogate biomarkers for identifying the risk for AD in normal cognitive (NC) adults, brain anatomical and functional alterations in amnestic mild cognitive impairment (aMCI), and Alzheimer's disease (AD) patients. Alzheimer's Disease PROCESS_OF Adult
22036957 Parsing of sound sources in the auditory environment or 'auditory scene analysis' is a computationally demanding cognitive operation that is likely to be vulnerable to the neurodegenerative process in Alzheimer's disease. Operative Surgical Procedures TREATS Alzheimer's Disease
22057784 Collectively, our data suggest that site-specific tau tyrosine nitration events occur in a disease and lesion-specific manner, indicating that nitration appears to be a highly controlled modification in AD and non-AD tauopathies. Alzheimer's Disease ISA Tauopathies
22057784 Selective tau tyrosine nitration in non-AD tauopathies. Alzheimer's Disease ISA Tauopathies
22114748 Effect of transcranial brain stimulation for the treatment of Alzheimer disease: a review. Brain stimulation TREATS Alzheimer's Disease
22114748 Available pharmacological treatments for Alzheimer disease (AD) have limited effectiveness, are expensive, and sometimes induce side effects. Pharmacological Treatment TREATS Alzheimer's Disease
22114748 The development of novel noninvasive methods of brain stimulation has increased the interest in neuromodulatory techniques as potential therapeutic tool for cognitive rehabilitation in AD. Cognitive Rehabilitation TREATS Alzheimer's Disease
22121477 Hypertension (HT) and dementia are common disorders in the elderly. Dementia PROCESS_OF Elderly
22121477 The Association between Hypertension and Dementia in the Elderly. Dementia PROCESS_OF Elderly
22121477 Data from two trials (Syst-Eur, PROGRESS) open the way toward the prevention of dementia (AD or VaD) by antihypertensive treatments. Alzheimer's Disease ISA Dementia

Note: PMID Link goes to the Article.

Substance Interactions

Found 40 predications. Showing 1 to 20
Pages: Prev 1 | 2 | Next
PMID Sentence Subject Predicate Object
21199446 The memory dysfunctions that characterize Alzheimer's disease (AD) are strongly correlated with synapse loss. Memory impairment COEXISTS_WITH Alzheimer's Disease
21234692 Previously, the novel image-novel location (NINL) object recognition test was shown to be sensitive to detect effects of apolipoprotein E4, a risk factor for developing age-related cognitive decline and Alzheimer's disease, in nondemented elderly. Alzheimer's Disease PROCESS_OF Elderly
21891973 In addition, curcumin labeled some diffuse SPs negative for Congo red in the AD, monkey, bear, and APP Tg-mouse brains. Curcumin TREATS Alzheimer's Disease
21891973 Some SPs in the AD, monkey, dog, bear, and amyloid precursor protein transgenic mouse (APP Tg-mouse) brains contained congophilic materials, and were intensely positive for curcumin. Senile Plaques COEXISTS_WITH Alzheimer's Disease
21911655 PARTICIPANTS: The intent-to-treat sample consisted of 104 adults with amnestic mild cognitive impairment (n = 64) or mild to moderate AD (n = 40). Alzheimer's Disease PROCESS_OF Adult
21911655 Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Insulin TREATS Alzheimer's Disease
21911655 OBJECTIVE: To examine the effects of intranasal insulin administration on cognition, function, cerebral glucose metabolism, and cerebrospinal fluid biomarkers in adults with amnestic mild cognitive impairment or Alzheimer disease (AD). Alzheimer's Disease PROCESS_OF Adult
21911655 OBJECTIVE: To examine the effects of intranasal insulin administration on cognition, function, cerebral glucose metabolism, and cerebrospinal fluid biomarkers in adults with amnestic mild cognitive impairment or Alzheimer disease (AD). Administration, Intranasal TREATS Alzheimer's Disease
21911655 Both insulin doses also preserved general cognition as assessed by the ADAS-cog score for younger participants and functional abilities as assessed by the ADCS-ADL scale for adults with AD (P < .05). Alzheimer's Disease PROCESS_OF Adult
21932048 This suggests that the primary mediator targeted by these drugs, PGE2, is not actively suppressing memory function in AD. Dinoprostone TREATS Alzheimer's Disease
21949904 This paper discusses recent findings of the multimodal MRI in the context of surrogate biomarkers for identifying the risk for AD in normal cognitive (NC) adults, brain anatomical and functional alterations in amnestic mild cognitive impairment (aMCI), and Alzheimer's disease (AD) patients. Alzheimer's Disease PROCESS_OF Adult
22036957 Parsing of sound sources in the auditory environment or 'auditory scene analysis' is a computationally demanding cognitive operation that is likely to be vulnerable to the neurodegenerative process in Alzheimer's disease. Operative Surgical Procedures TREATS Alzheimer's Disease
22057784 Collectively, our data suggest that site-specific tau tyrosine nitration events occur in a disease and lesion-specific manner, indicating that nitration appears to be a highly controlled modification in AD and non-AD tauopathies. Alzheimer's Disease ISA Tauopathies
22057784 Selective tau tyrosine nitration in non-AD tauopathies. Alzheimer's Disease ISA Tauopathies
22114748 Effect of transcranial brain stimulation for the treatment of Alzheimer disease: a review. Brain stimulation TREATS Alzheimer's Disease
22114748 Available pharmacological treatments for Alzheimer disease (AD) have limited effectiveness, are expensive, and sometimes induce side effects. Pharmacological Treatment TREATS Alzheimer's Disease
22114748 The development of novel noninvasive methods of brain stimulation has increased the interest in neuromodulatory techniques as potential therapeutic tool for cognitive rehabilitation in AD. Cognitive Rehabilitation TREATS Alzheimer's Disease
22121477 Hypertension (HT) and dementia are common disorders in the elderly. Dementia PROCESS_OF Elderly
22121477 The Association between Hypertension and Dementia in the Elderly. Dementia PROCESS_OF Elderly
22121477 Data from two trials (Syst-Eur, PROGRESS) open the way toward the prevention of dementia (AD or VaD) by antihypertensive treatments. Alzheimer's Disease ISA Dementia

Diagnosis

Same As Above

Pharamcogenomics

Same As Above

Select Each of the Concepts and Summarize to Get the Number of Predications for Each (Total 379?)

NEXT

Page statistics
528 view(s) and 4 edit(s)
Social share
Share this page?

Tags

This page has no custom tags.
This page has no classifications.

Comments

You must to post a comment.

Attachments